doi: 10.1111/j.1469-8749.1988.tb04799.x 5
The product also downregulates lipogenic genes (e.g., FAS, SREBP1c), further improving hepatic lipid metabolism-again via nicotinamide regulation and NAD+ homeostasis
In mouse models of highfat dietinduced liver steatosis, it significantly inhibits hepatic NNMT activity, reduces NAM methylation, increases NAD+ and SAM levels, enhances mitochondrial fatty acid oxidation, reduces hepatic triglyceride and lipid accumulation, lowers lipotoxicity markers (e.g., malondialdehyde, transaminases), improves hepatocellular injury, and reverses steatosis
Cardiovascular Benefits Evidence suggests direct cardiac benefits independent of anti-obesity properties
Three volumes are used most often in research settings: 1mL, 2mL, and 5mL